Top Definition
A generic phrase to describe any sexually transmitted disease, or as a shorthand to describe having multiple STDs. Some dispute exists as to the proper spelling, but either "Big Louie" or "Big Louis" is acceptable.
Dude, if a chick ever makes you get tested for the Big Louie, make sure to piss in the cup instead of letting them stick that huge q-tip in there, that shit hurts.
#big louis #big louie #louie #big lewey #sexually transmitted disease #std #venereal disease #vd #gonerrhea #crabs #hpv #syphilis #hepatitis #herpes #hiv #aids #chlamydia #scabies #ngu #pid #vaginitis
ayon kay No Big Louie ika-16 ng Nobyembre, 2006
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