A term for an addiction to the band System of a Down
Mike listens to System of a Down all day, he has down syndrome.
ayon kay m-dubya ika-28 ng Mayo, 2005
What you call someone who has recently been an idiot, asked an extremely stupidass question or is just a flat-out moron.
Person one: hey look at me i'm licking the floor

Person two: ... do you have fucking down syndrome?

Person one: is the Earth flat?

Person two: you have down syndrome.
ayon kay Knee-Grow10 ika-17 ng Abril, 2007
an insult, to say to ones friends when they are acting 'crippled'
Clutch, are you fuckin down syndrome!
ayon kay 106_joN ika-27 ng Marso, 2005
A phrase used to make fun of someone after they have done something stupid. Also, a disease similar to mental retardation. Many people who have down syndrome have competed in the Special Olympics.
What the hell is your problem! Are you down syndrome or something?
ayon kay J-dog ika-09 ng Abril, 2005
very strange...and exessively weird
cara is the coolest kid with down syndrome i know
ayon kay ilovematthew ika-08 ng Mayo, 2006
A Retard.
That fat stupid fuck has down syndrome and, like a mule, ill-bred dog, or sci-fi mutant, cannot reproduce - a likely fail safe implemented by Mother Nature to prevent such horrid monsters from fucking up the entire human race.
ayon kay CynicalSnake ika-22 ng Agosto, 2016
A condition where you have an extra chromosome. The normal amount of chromosomes is 46, and with Down syndrome you have 47.
Diego Reyes has mad Down syndrome.
ayon kay Are you Tweakin ika-29 ng Mayo, 2016
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