Urinating (number one) and defecating (number two) simultaneously.
Joe: Damn I got to go.
Jim: Number one or number two?
Joe: Both, bro'.. number three!
ayon kay Joe Bone ika-08 ng Marso, 2005
Rhyming slang for wee or pee (urinate).

Same as 'number two' is rhyming slang for poo.
Are you going to the toilet to do a number two or number three?
ayon kay StephenSLR ika-24 ng Agosto, 2011
Wee, pee, urinate.

Comes from the childrens nursery rhyme:

Number one, tickle my bum

Number two, do a big poo

Number three, go for a wee
Don't drink too much before bed you'll have to go number three in the middle of the night
ayon kay Jaspur ika-29 ng Oktubre, 2011
Taking a shower immediately after dropping anchor. It's called a number three because it should ALWAYS follow a number two. If you don't agree, then here is what will convince you: If you get poop on your hand and wipe it off with a dry piece of toilet paper YOUR HAND WILL STILL SMELL LIKE POOP! (shock)
Aaron Desselle always goes home from work to take a number three. His butt is clean right now.
ayon kay a-diggity ika-29 ng Hunyo, 2004
ecstasy.

Due to a ranking of drugs. It's still in the works. All drugs have not been tried/ranked yet.

see number two
What are you doing tonight?
About to get me some of that number three.

What are they on right now?
They are hella number threed out!
ayon kay Urban Dictionary ika-14 ng Nobyembre, 2008
The dreaded third shit of the morning, usually hits as soon as you either take a shower or leave the house.
My god that cheap draft is haunting me now! Number Three came knockin as soon as I walked out the door!

As I was drying off after a hot shower, number three hit with a vengeance not often seen in this universe and I had to dirty my clean arse....goddammitt!!
ayon kay Lunicus ika-09 ng Pebrero, 2013
Mixture of pee and poop - diharreah.
Number one - Pee
Number two - Poop
Number three - Diharreah
ayon kay holymoley222 ika-22 ng Disyembre, 2013
When you have extremely bad diarrhea or thin watery feces. It is often the cause of spicy food and Taco Bell.
"Hey, can we go I have to pee...?"
"Dude, don't be a fag, go in the trees."
"...from my ass."
(Number Three)
ayon kay nirog ika-08 ng Oktubre, 2007

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