Since God has been in continuous decline and not trending well at all, popular phrases involving him are being revised to fit today's modern, secular world.
OMFS!!! I can't believe he's botoxing his ballbag!
OMFS! I heard Mr Fisher cloned his wife so he can fuck her every night like he did when they first met.
The neckbearded may also use "OMFS" as an acronym for "oh my fucking science" or "oh my fucking Satan" because "stars" are perceived as insufficiently secular, despite the fact that neckbeards believe that our molecules came from exploding stars, and that monkeys and fish fucked each other to create yo bitchass.
Although "OMFS" is generally used to express surprise, atheists also use it to express their hatred of christfags and our lord and savior, Jesus Christ. Of Nazareth.
Yes, that Jesus Christ.
OMFS! Did you see that furry's throbbing, black furcock?!
OMFS! Dawkins damn it.