A slang term for a grandfather. Used in many southern states, including Texas, Arkansas, Georgia, and Louisiana.
"Hey Pepa! Where you goin'?"

"I'm headin' back into the house to get your Mema."
ayon kay texarkanaborn ika-02 ng Nobyembre, 2012
In Mexico: its one of several slang terms used for a girl's pussy a.k.a. vagina.

En Mexico es una palabra conocida como la chocha de una mujer.. alias Vagina.
1. She said her pepa gets wet when she gets aroused.

2. Ella dice que se le moja la pepa cuando se excita.
ayon kay chocu ika-28 ng Nobyembre, 2006
In Colombia: A person whose intelligence is above the average.
Someone characterized for being smarter than others.
Carlos es el mas pepa de la clase.
ayon kay Mario F Monsalve ika-12 ng Disyembre, 2005
A nickname for someone's grandfather.
Me: "Aunt Maria, have you seen Pepa?"

Aunt Maria: "Yeah, he went out with Mema."
ayon kay CrystellaMarie ika-23 ng Oktubre, 2008

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