Prostitutitis is a term used to describe those who have made the unfortunate mistake of making untasteful jokes which lead people to think that they sell themselves on street corners.
Person A: "Your boyfriend is so happy he's with you,"

Person B: "Yup, I try to give them my money's worth!" (joking)

Person A: "OMG! SHE MUST BE, LIKE, A PROSTITUTE!"

Hence, Person B has 'prostitutitis'.
ayon kay Ella Balser ika-30 ng Setyembre, 2011
Noun: A person, usually a female or homosexual, that is a complete and utter filthy skank that has or has had diseases or is BOUND to have a disease due to his/her/it's promiscuous behavior.

Adverb: Used to describe an affliction that's very common in hookstitutes, skankstitutes, skunts, whores and myriad types of harlots
Crackers: What up prostitutitis?
Platanera: Nothing much nagger

Crackers: Damn son, look at that hoe, don't tell me you be messin 'round with that bitch. She gots that prostitutitis you know.
ayon kay Hexs_Vice ika-19 ng Enero, 2009

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