Top Definition
A greeting of spiritual affirmation between friends - can be used in form of "Hello" or "Goodbye".
"Bless up, brother"
"hey hey, what's going on?"

or

"See you tomorrow, mate"
"Bless up"
ayon kay VBR213 ika-10 ng Oktubre, 2009
God be with you, general wishes of well being be upon you.
'blessup yo' self foo'
ayon kay Psyda ika-28 ng Hulyo, 2008
DJ Khaled a spiritual leader uses this term to indicate his thankfulness to god. It can be used as greetings, after hearing good or bad news. The meaning is not quite clear but it's usage is. Bless up.
Random Dude:Yo! Star wars just came out :D
Major DJ Khaled Fan: Bless Up
ayon kay Lord Vignesh ika-16 ng Abril, 2016
A term used by celebrity DJ Khaled in order to show reverence to God, or give gratitude to what he has given to you in an opportunity. Also used after hearing something nice, greeting friends, or randomly interjecting statements.
Random Kid: I got an A on the final
DJ Khaled Follower: Bless Up, LIOOON.
ayon kay Lord Vignesh ika-21 ng Abril, 2016
A retard's way of saying "God Bless you." because their brain has a lower processing power than a potato.
Man 1: Hey, how's it going?
Man 2: Bless Up! Heh, YOLO man!
ayon kay D33tly ika-14 ng Abril, 2016
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