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Acronym for 'Crying My Face Off.' Often used in games after losing to another player or when speaking emotionally online about relationships or anything related to crying.
I can't believe I lost! I'm going to bed CMFO.

When she dumped me I was CMFO, but later I was like WTF!?
ayon kay mercboyan ika-26 ng Setyembre, 2008
Chief Mother Fucking Officer
That lady killer just made it rain again at the club tonight -he is one CMFO
ayon kay El Jefe CMFO ika-03 ng Agosto, 2010