Used as a verb in a threatening tone, can be used to mean "fuck up," "kill," etc...
You fuckin' touch me again and I'll differentiate ya!
ayon kay Jason McAaron ika-14 ng Mayo, 2008
Another word for difference.
J: Wow she looks a lot like her sister.
Y: Yea it's hard to differentiate.

(difficult to see the difference)
ayon kay Rebanex ika-05 ng Marso, 2008
to distinguish from similar options
What differentiated this start-up portal was a relationship with urbandictionary.com
ayon kay Alexander Zubatov ika-17 ng Marso, 2007

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