the generic name for a date rape drug
Hey i slipped Anna ruffies this weekend.
ayon kay blackdahlia ika-19 ng Pebrero, 2004
A bocce throw, when the ball is thrown overhand as hard as possible to know the other teams ball away from the palino. The name Ruffe stems from the generic date rape drug name, and with both the date rape drug, and this throw, the main purpose is to knock out the target.
"Go for a Ruffe so they dont score their ninth point and win this round."
ayon kay Bocceman ika-25 ng Setyembre, 2009
Something someone slips into a girl's drink so he can have sex with her
Peter wants to slip a ruffe into Tara's drink so he can have sex with her.
ayon kay Paul ika-30 ng Marso, 2005

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