Some one who is messed up or deformed.

Someone who is stupid or ugly.

Someone who is screwed or in a screwed up situation.

Someone who doesn't make sense
That dude over there is one screwed up ugly retard.

You are so screwed up.
ayon kay Jonathan Hoffman ika-12 ng Oktubre, 2002
music slowed to slowed tempo,creating a surreal sound a kind of dillusional state of mind. popular in the city of houston, tex aka screwston... made popular by the late great DJ SKREW..
all my music is screwed up...
you got the screwed up version of that slim thugga cd...
ayon kay C-MO ika-10 ng Hulyo, 2005
to have sex with someone way above your social, economic or hotness scale
Dude, I nailed a super-model last night

now way! you really screwed up!!
ayon kay oilcan905 ika-07 ng Oktubre, 2009
1) adj: perverted. Being perverted.
2) adj: Stupid.
1) I'm really screwed up: I've written m/mRPS

2) Man, that soda machine is really screwed up. It costs 3$ for a soda!
ayon kay katrine ika-11 ng Abril, 2004
A song from Ludacris' recent album:
Chicken -N- Beer
I feel betta than i eva felt before (ah)
Intoxicated but maintainin self control(ahh)
I took a swig I had a jug
Jug-a-lug I'm loud and clear
I had some bud I lit it up and then i made it disappear
Cause my magic tricks are so fabulous the sh*t's hazerdous got ameturs smokin canibus if you mad at this d*mn it then

Fuck you (fuck you)
fuck you (fuck you)
fuck you (fuck you)
fuck you (fuck you)

I'm screwed up
ayon kay Breyanna ika-31 ng Enero, 2004

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