When one is in a situation that is so abhorrent that it couldn't possibly get any worse. The phrase "screwed with a capital S" just does not cut it when describing how horrible it is.
Person 1: Hey, man, you're twitching. What the hells wrong?

Person 2: Oh nothing, JUST MY LAPTOP CONTAINING MY 500 PAGE THESIS ON THE CURRENT GLOBAL ECONOMY CRASHED AND ITS DUE TOMORROW.. ya know, the usual shit

Person 1: Wow.. that sucks, dude.

Person 2: I know. Im screwed with a capital FUCK!!!
ayon kay xx<3Katie<3xx ika-23 ng Disyembre, 2009

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