1)Despite its original intentions, it is most often interpreted as "Stuff You" written in shorthand.
2)Intended to mean shut the f**k up.
Hey, stfu man.
ayon kay Willy Johnson ika-04 ng Nobyembre, 2003
Used to mean Shut the "F" up, also means Step the "F" up.
"If you think you are man enough, then STFU and prove it".(Reference to the phrase, "Cowboy up"). Of course both phrases are commonly used together.
"If you think you are man enough, then STFU (Step The "F" Up) and prove it, otherwise STFU (Shut The "F" Up) and sit your ass down".
ayon kay Cable Kenn ika-24 ng Pebrero, 2006
Shortened Version of "Shut the Fuck up!" Used commonly by people in Britan and England, also on such things like AIM, MSN, and Yahoo Messenger.

Literally, they are telling you to bang that girl more quietly, producing less orgasms. Go bang that person who said STFU with a crowbar in the ass.
Guy: "STFU"
Guy 2: "You go fuck it, or I shove a crowbar up yo hole!"
Guy: "What? Go Rape a bus!"
ayon kay W/e ika-09 ng Marso, 2005
1. An abbreviation for Shut The Fuck Up.

2. An abbreviation for STupid FUcker
STFU n00b stop being gay.
ayon kay vipa!!! ika-04 ng Nobyembre, 2005
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