Top Definition
Verb. A side effect of extreme over indulgence in crystal meth or crack cocaine. Tweekers typically perform OCD-like activities centered around finding small quantities of drugs that were inadvertently "misplaced". Tweekers may be seen on all fours, searching in gutters, obsessively looking under various objects and so on. In certain circumstances, extreme tweeking resembles autism or catatonia.
Yo! Check out that tweeking crack ho!
ayon kay Slagathor ika-23 ng Abril, 2004
29 more definitions
A character from the TV show "South Park". Tweek is the ADD kid, who is constantly twitching. He often rants and raves about things that only he sees, and is addicted to coffee. Tweek is in love with Craig, and they sex each other.
Wow. Tweek sure has sex with Craig a lot. It's hot.
ayon kay The Lord Of Spam ika-16 ng Pebrero, 2006
losing oneself in a senseless task while under the influence of speed.
She would tweek all night cleaning the house and pulling apart electronic devices.
ayon kay chillcat ika-29 ng Mayo, 2003
the nervous ticks or twitching one experiances as they come down from a crystal methamphetamine binge.
pulling hairs out of their face; picking at their face; picking their nose...
ayon kay a former tweeker ika-28 ng Nobyembre, 2003
Upper, crystal meth
can I have a bump of tweek?
ayon kay Cosmo Wash.DC ika-26 ng Disyembre, 2002
to adjust or fix
Let me just tweek your computer.
ayon kay Tracy Lukeman ika-20 ng Oktubre, 2003
Similar to a Gleek, the Tweek is the Twilight version. Geek + Twilight = Tweek
OMG I am sooo excited to go and see the new Twilight movie, I'm such a Tweek!!
ayon kay Sazilicious ika-02 ng Hulyo, 2010

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